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LSD molecule image.png
Abstract Futuristic Background

Pharmacology of LSD

LSD and serotonin comparison

Learn how LSD works in the brain

from a molecular perspective

LSD molecule
Abstract Futuristic Background

Lysergic acid diethylamide (LSD) is a monoaminergic psychedelic with a chemical structure very similar to the neurotransmitter serotonin. Upon consumption, the LSD molecule crosses the blood-brain barrier and binds to 8 different serotonin receptors mainly the 5HT2A  receptor. LSD binding agonizes (binds to) this receptor and causes an increase in 5HT2A serotonin firing. The proposed reason for LSD's lengthy duration is due to the formation of a "lid" on the serotonin receptor. It is believed that the LSD molecule creates a type of lid that hinders the reuptake of the molecule, making it more difficult for it to be broken down and removed from the serotonin receptor. This prolonged interaction with the receptor contributes to the extended effects of LSD compared to endogenous (naturally occurring) serotonin.

LSD pharmacology chart

LSD analogues
(drugs similar to LSD)

         LSD is illegal and completely unregulated since it is produced and distributed illegally the purity, dose, and substance is unknown when dealing with LSD. When people say LSD they mean the chemical Lysergic acid diethylamide. There are many analogues of LSD that are known and being researched. A drug analogue is a chemical that looks and behaves very similarly to another chemical while having very slight differences. For example, Lysergic acid diethylamide (LSD) has a very similar chemical called 1p-LSD. The 1p-lsd molecule looks nearly identical to someone without a background in chemistry but there is a slight difference between LSD and 1p-LSD. Both chemicals are psychoactive and cause psychedelic effects but LSD is schedule 1 illegal and 1p-LSD is considered a research chemical and not directly illegal. The Federal analogue act of 1986 in the United States stated that a chemical that is substantially similar to an illegal drug should be considered illegal as well but only if the chemical is intended for human consumption. Some research companies in Canada legally distribute analogues of LSD such as 1p-LSD, 1b-LSD, 1v-LSD. All these chemicals are very similar to LSD but not exactly the same. There are definitely differences between them but they are all psychedelic and are measured in microgram doses similar to Lysergic Acid diethylamide (regular LSD).

1p-lsd tab
1p-lsd tab

(both tabs contain 1p-LSD)

Sometimes analogues

are on labeled blotter paper. 

Most analogues are meant to trick buyers into thinking it is real LSD.

1p-lsd vs lsd

1-propanoyl-lyserigic acid diethylamine

Colorful Lights

Fun fact

LSD was made on accident by Swiss scientist Albert Hoffman in 1943. He dosed himself by mistake and experienced the first LSD trip ever!

Albert Hoffman

ALBERT HOFFMAN: THE CREATOR OF LSD

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